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Theaflavin Effects
1. Bacteriostatic and antiviral effects. A large number of studies have shown that theaflavins have inhibitory effects on a variety of bacteria, including Clostridium botulinum, Enterobacteriaceae, Staphylococcus aureus, Podococcus, Bacillus cereus, Shigella bacteria and caries-causing bacteria found so far.
2. Regulation of lipid metabolism. Li Fu et al. (2008) explored the effect of TF on the differentiation of rabbit bone marrow stromal stem cells to adipocytes at the cellular level, and the results showed that TF could significantly inhibit the differentiation of rabbit bone marrow stromal stem cells to adipocytes. Sun Shili et al. (2011) found that tea polyphenols and TF significantly inhibited the differentiation of preadipocytes from mouse embryonic fibroblasts. The content of triacylglycerol in the differentiated cells was significantly reduced, indicating that tea polyphenols and TF had a better inhibitory effect on the proliferation and differentiation of preadipocyte mouse embryonic fibroblasts. In addition to the physiological functions mentioned above, TF also has the physiological functions of anti-infective, anti-cardiovascular disease and inhibition of femoral head necrosis.
3. Anti-cancer. Transcription factor AP-1 is a protein encoded by gene c-jun (a proto-oncogene), which is an important regulatory protein in the process of apoptosis and an important factor in tumourigenesis. Studies have shown that TF analogues can effectively inhibit the action of AP-1 induced by outdoor ultraviolet light. This inhibits tumourigenesis at the initiation stage ( Masaaki Nomura et al., 2000). Nuclear factor (NF - kB) has an important role in inflammation and immune regulation. They concluded that IF3 is effective in preventing cancer precisely by inhibiting the action of NF - kB and IKK. Feng et al. (2002) demonstrated that TF can prevent cancer by decreasing the number of cells in culture. (2002) showed that TF could prevent DNA damage in cells by reducing oxidative stress and cytochrome P4501A1 in cell culture. Liqiong et al. (2011) showed that TF bis-gallate inhibited the growth of A549 cells, promoted their demise, and inhibited the expression of vascular endothelial growth factor (VEGF) mRNA.